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phenobarbital will lessen the level or effect of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.phenobarbital will lower the level or effect of alfuzosin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.phenobarbital will lower the extent or impact of ritleciti